GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in a human iPSC model of Alexander disease

Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Stem Cell
Κύριοι συγγραφείς: Li, Li, Tian, E, Chen, Xianwei, Chao, Jianfei, Klein, Jeremy, Qu, Qiuhao, Sun, Guihua, Sun, Guoqiang, Huang, Yanzhou, Warden, Charles D., Ye, Peng, Feng, Lizhao, Li, Xinqiang, Cui, Qi, Sultan, Abdullah, Douvaras, Panagiotis, Fossati, Valentina, Sanjana, Neville E., Riggs, Arthur D., Shi, Yanhong
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230521/
https://ncbi.nlm.nih.gov/pubmed/30075130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.07.009
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