Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation

BACKGROUND: Multidrug resistance remains a major obstacle to successful treatment for patients with gastric cancer (GC). Recently, glycosylation has been demonstrated to play a vital role in the acquisition of multidrug resistance. As a potent inhibitor of glycosylation, tunicamycin (Tu) has shown m...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Wu, Jian, Chen, Sheng, Liu, Hao, Zhang, Zhe, Ni, Zhen, Chen, Jie, Yang, Zhiping, Nie, Yongzhan, Fan, Daiming
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230241/
https://ncbi.nlm.nih.gov/pubmed/30413206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0935-8
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