RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

The two Ral GTPases, RalA and RalB, have crucial roles downstream Ras oncoproteins in human cancers; in particular, RalB is involved in invasion and metastasis. However, therapies targeting Ral signalling are not available yet. By a novel optogenetic approach, we found that light-controlled activati...

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Pubblicato in:eLife
Autori principali: Zago, Giulia, Veith, Irina, Singh, Manish Kumar, Fuhrmann, Laetitia, De Beco, Simon, Remorino, Amanda, Takaoka, Saori, Palmeri, Marjorie, Berger, Frédérique, Brandon, Nathalie, El Marjou, Ahmed, Vincent-Salomon, Anne, Camonis, Jacques, Coppey, Mathieu, Parrini, Maria Carla
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226288/
https://ncbi.nlm.nih.gov/pubmed/30320548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40474
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