Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart

Mitochondrial Ca(2+) elevations enhance ATP production, but uptake must be balanced by efflux to avoid overload. Uptake is mediated by the mitochondrial Ca(2+) uniporter channel complex (MCUC), and extrusion is controlled largely by the Na(+)/Ca(2+) exchanger (NCLX), both driven electrogenically by...

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Vydáno v:Cell Rep
Hlavní autoři: Fuente, Sergio De La, Lambert, Jonathan P., Nichtova, Zuzana, Sanz, Celia Fernandez, Elrod, John W., Sheu, Shey-Shing, Csordás, György
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226263/
https://ncbi.nlm.nih.gov/pubmed/30231993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.040
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