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Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart
Mitochondrial Ca(2+) elevations enhance ATP production, but uptake must be balanced by efflux to avoid overload. Uptake is mediated by the mitochondrial Ca(2+) uniporter channel complex (MCUC), and extrusion is controlled largely by the Na(+)/Ca(2+) exchanger (NCLX), both driven electrogenically by...
Kaydedildi:
| Yayımlandı: | Cell Rep |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6226263/ https://ncbi.nlm.nih.gov/pubmed/30231993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.040 |
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