The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions

Supplemental levels of vitamin B1 (thiamine) have been implicated in tumor progression. Tumor cells adaptively up-regulate thiamine transport during hypoxic stress. Upon uptake, thiamine pyrophosphokinase-1 (TPK1) facilitates the rapid phosphorylation of thiamine into thiamine pyrophosphate (TPP). H...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jonus, Hunter C., Hanberry, Bradley S., Khatu, Shivani, Kim, Jaeah, Luesch, Hendrik, Dang, Long H., Bartlett, Michael G., Zastre, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226039/
https://ncbi.nlm.nih.gov/pubmed/30459934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26259
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