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Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D(2) Receptor Ligand

Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of aminergic GPCRs) and synthesized in the reaction of 5-ethoxyindole and 1-benzyl-4-piperidone. This compound has an affinity to the human dopam...

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Dettagli Bibliografici
Pubblicato in:Molecules
Autori principali: Kondej, Magda, Bartyzel, Agata, Pitucha, Monika, Wróbel, Tomasz M., Silva, Andrea G., Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225423/
https://ncbi.nlm.nih.gov/pubmed/30181442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23092249
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