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Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling

Veratrum californicum is a rich source of steroidal alkaloids such as cyclopamine, a known inhibitor of the Hedgehog (Hh) signaling pathway. Here we provide a detailed analysis of the alkaloid composition of V. californicum by plant part through quantitative analysis of cyclopamine, veratramine, mul...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Turner, Matthew W., Cruz, Roberto, Elwell, Jordan, French, John, Mattos, Jared, McDougal, Owen M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225318/
https://ncbi.nlm.nih.gov/pubmed/30200443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23092222
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