Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion

Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow (BM) cells expressing TNF is increased in MF compared to controls, with...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Leukemia
Egile Nagusiak: Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224399/
https://ncbi.nlm.nih.gov/pubmed/29749399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0131-z
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