Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

Chagas disease, caused by Trypanosoma cruzi, affects millions of people in South America and no satisfactory therapy exists, especially for its life threatening chronic phase. We targeted the Proline Racemase of T. cruzi, which is present in all stages of the parasite life cycle, to discover new inh...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Amaral, Patricia de Aguiar, Autheman, Delphine, de Melo, Guilherme Dias, Gouault, Nicolas, Cupif, Jean-François, Goyard, Sophie, Dutra, Patricia, Coatnoan, Nicolas, Cosson, Alain, Monet, Damien, Saul, Frederick, Haouz, Ahmed, Uriac, Philippe, Blondel, Arnaud, Minoprio, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224121/
https://ncbi.nlm.nih.gov/pubmed/30372428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006853
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