The JAK2V617F Point Mutation Increases the Osteoclast Forming Ability of Monocytes in Patients with Chronic Myeloproliferative Neoplasms and Makes their Osteoclasts more Susceptible to JAK2 Inhibition

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and f...

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Détails bibliographiques
Publié dans:Mediterr J Hematol Infect Dis
Auteurs principaux: Spanoudakis, Emmanouil, Papoutselis, Menelaos, Bazdiara, Ioanna, Lamprianidi, Eleftheria, Kordella, Xrisa, Tilkeridis, Constantinos, Tsatalas, Costas, Kotsianidis, Ioannis
Format: Artigo
Langue:Inglês
Publié: Università Cattolica del Sacro Cuore 2018
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223546/
https://ncbi.nlm.nih.gov/pubmed/30416690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4084/MJHID.2018.058
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