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Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
BACKGROUND: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the activity of p53 protein through working as ubiquitin E3 ligase promoting p53 degr...
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| Yayımlandı: | Drug Des Devel Ther |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Dove Medical Press
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6223338/ https://ncbi.nlm.nih.gov/pubmed/30464405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S182444 |
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