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Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail
BACKGROUND: The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are dismal. Patients are being let down by the current system of drug discovery; of the several 1000 diseases that affect humans, only a minority have any approved treatmen...
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| Publicado no: | J Transl Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6223056/ https://ncbi.nlm.nih.gov/pubmed/30404629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1678-1 |
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