Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation

Protein tyrosine phosphatases (PTPs) contribute to a striking variety of human diseases, yet they remain vexingly difficult to inhibit with uncharged, cell-permeable molecules; no inhibitors of PTPs have been approved for clinical use. This study uses a broad set of biophysical analyses to evaluate...

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Vydáno v:Biochemistry
Hlavní autoři: Hjortness, Michael K., Riccardi, Laura, Hongdusit, Akarawin, Ruppe, Alex, Zhao, Mengxia, Kim, Edward Y., Zwart, Peter H., Sankaran, Banumathi, Arthanari, Haribabu, Sousa, Marcelo C., De Vivo, Marco, Fox, Jerome M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219988/
https://ncbi.nlm.nih.gov/pubmed/30169954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00655
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