Helminth-Induced Production of TGFβ and Suppression of Graft-Versus-Host Disease Is Dependent on Interleukin-4 Production by Host Cells

Helminths stimulate the secretion of T helper 2 (Th2) cytokines, like interleukin-4 (IL4) and suppress lethal graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). This suppression depends on the production of immune-modulatory TGFβ and is associated with TGFβ-dependent in vivo e...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Li, Yue, Guan, Xiaoqun, Liu, Weiren, Chen, Hung-Lin, Truscott, Jamie, Beyatli, Sonay, Metwali, Ahmed, Weiner, George J., Zavazava, Nicholas, Blumberg, Richard S., Urban, Joseph F., Blazar, Bruce R., Elliott, David E., Ince, M. Nedim
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219912/
https://ncbi.nlm.nih.gov/pubmed/30291167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700638
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