Protective effect of a mechanistic target of rapamycin inhibitor on an in vivo model ofcisplatin-induced ovarian gonadotoxicity

This study aimed to evaluate the protective effect of everolimus, a mechanistic target of rapamycin (mTOR) inhibitor, on cisplatin chemotherapy-induced ovarian toxicity. Eighty sexually mature, virgin, female, 7-week-old C57BL/6J mice were divided into four groups: control, cisplatin (Cis), everolim...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Exp Anim
Hauptverfasser: Tanaka, Yuji, Kimura, Fuminori, Zheng, Luyi, Kaku, Shoji, Takebayashi, Akie, Kasahara, Kyoko, Tsuji, Shunichiro, Murakami, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Japanese Association for Laboratory Animal Science 2018
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Original
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219883/
https://ncbi.nlm.nih.gov/pubmed/29937473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.18-0042
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