Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular prolif...

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Bibliografski detalji
Izdano u:PLoS Biol
Glavni autori: Pentland, Ieisha, Campos-León, Karen, Cotic, Marius, Davies, Kelli-Jo, Wood, C. David, Groves, Ian J., Burley, Megan, Coleman, Nicholas, Stockton, Joanne D., Noyvert, Boris, Beggs, Andrew D., West, Michelle J., Roberts, Sally, Parish, Joanna L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219814/
https://ncbi.nlm.nih.gov/pubmed/30359362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005752
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