Characterisation of homologous recombination deficiency in paired primary and recurrent high-grade serous ovarian cancer

BACKGROUND: Homologous recombination deficiency (HRD) is shown to predict response to DNA-damaging therapies in patients with high-grade serous ovarian cancer (HGSOC); however, changes in HRD during progression remains unknown. METHODS: HRD scores were evaluated in paired primary and/or recurrent HG...

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Vydáno v:Br J Cancer
Hlavní autoři: Patel, Jai N., Braicu, Ioana, Timms, Kirsten M., Solimeno, Cara, Tshiaba, Placede, Reid, Julia, Lanchbury, Jerry S., Darb-Esfahani, Silvia, Ganapathi, Mahrukh K., Sehouli, Jalid, Ganapathi, Ram N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219476/
https://ncbi.nlm.nih.gov/pubmed/30318511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0268-6
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