Balanced Activity between Kv3 and Nav Channels Determines Fast-Spiking in Mammalian Central Neurons

Fast-spiking (FS) neurons can fire action potentials (APs) up to 1,000 Hz and play key roles in vital functions such as sound location, motor coordination, and cognition. Here we report that the concerted actions of Kv3 voltage-gated K(+) (Kv) and Na(+) (Nav) channels are sufficient and necessary fo...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Gu, Yuanzheng, Servello, Dustin, Han, Zhi, Lalchandani, Rupa R., Ding, Jun B., Huang, Kun, Gu, Chen
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218699/
https://ncbi.nlm.nih.gov/pubmed/30390433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.10.014
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