Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain

Prostate cancer (PCa) often recurs as incurable castration‐resistant prostate cancer (CRPC) after the failure of androgen deprivation therapy. CRPC development relies on androgen receptor (AR) signaling. The IL6/STAT3 pathway is also a key driver of CRPC. The crosstalk between IL6/STAT3 and the AR p...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Hua, Yaping, Azeem, Waqas, Shen, Yunheng, Zhang, Shoude, Olsen, Jan R., Øyan, Anne M., Ke, Xisong, Zhang, Weidong, Kalland, Karl‐Henning
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218398/
https://ncbi.nlm.nih.gov/pubmed/30410767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.437
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