Apoptosis signal-regulating kinase 1 (ASK1) inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease (COPD)

Increased airway smooth muscle (ASM) mass is observed in chronic obstructive pulmonary disease (COPD) which is correlated with disease severity and negatively impact lung function in these patients. Thus, there is clear unmet clinical need for finding new therapies which can target airway remodeling...

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Publicado en:Clin Sci (Lond)
Main Authors: Eapen, Mathew S, Kota, Anudeep, Vindin, Howard, McAlinden, Kielan D, Xenaki, Dia, Oliver, Brian G, Deshpande, Deepak A, Sohal, Sukhwinder Singh, Sharma, Pawan
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218165/
https://ncbi.nlm.nih.gov/pubmed/30006481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20180398
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