PDTM-26. DUAL THERAPY WITH PI3K INHIBITOR ZSTK-474 AND MEK INHIBITOR TRAMETINIB VIA CONVECTION-ENHANCED DELIVERY IN A GENETICALLY-ENGINEERED MOUSE MODEL OF DIFFUSE INTRINSIC PONTINE GLIOMA

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with a median survival of less than one year. Prior studies have highlighted PI3K/AKT signaling amplifications in DIPG. However, compensatory activation of parallel pathways, e.g. MAPK, may lead to resistance to PI3K in...

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Publicado en:Neuro Oncol
Autores principales: Chang, Raymond, Tosi, Umberto, Bhanu Maachani, Uday, Voronina, Iuliia, Schweitzer, Melanie, Wu, Linda, Souweidane, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217669/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.867
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