Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model

Inguinal hernia develops primarily in elderly men, and more than one in four men will undergo inguinal hernia repair during their lifetime. However, the underlying mechanisms behind hernia formation remain unknown. It is known that testosterone and estradiol can regulate skeletal muscle mass. We her...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhao, Hong, Zhou, Ling, Li, Lin, Coon V, John, Chatterton, Robert T., Brooks, David C., Jiang, Enze, Liu, Li, Xu, Xia, Dong, Zhiyong, DeMayo, Francesco J., Stulberg, Jonah J., Tourtellotte, Warren G., Bulun, Serdar E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217386/
https://ncbi.nlm.nih.gov/pubmed/30327348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807765115
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