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PATH-31. GIANT CELL GLIOBLASTOMAS: ANALYSIS OF MISMATCH-REPAIR (MMR) PROTEINS EXPRESSION, POLIMERASE ε (POLE) MUTATIONS AND THEIR ROLE IN TUMOR IMMUNORESPONSE
Giant cell glioblastoma (gcGBM) is a rare (<1%) variant glioblastoma (GBM), in younger patients. Unlike the IDH-wild type GBM, they have a better prognosis. Mutations in the POLE and in MMR genes accelerate tumorigenesis, generating in some tumours an ultra-mutated phenotype. The lack of proofrea...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216707/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.687 |
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