STEM-11. DIRECTED NEURONAL DIFFERENTIATION AS A THERAPEUTIC STRATEGY FOR MALIGNANT GLIOMAS

IDH-mutant (IDH-MUT) glioma patients show highly improved prognosis compared to those with wild-type IDH. However, IDH mutations are rare in the more aggressive grade IV glioblastomas and introducing IDH mutations in mouse neural cells does not induce gliomagenesis. This is a paradox, given that IDH...

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Vydáno v:Neuro Oncol
Hlavní autoři: Audia, Alessandra, Ravikumar, Visweshwaran, Deng, Zhong, Murali, Vineeth, Balasubramaniyan, Veerakumar, de Groot, John, Rao, Arvind, Bhat, Krishna
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216192/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1018
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