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Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by accumulation of amyloid β-peptide (Aβ) plaques in the brain and decreased cognitive function leading to dementia. We tested if hydroxyurea (HU), a ribonucleotide reductase inhibitor known to activate adaptive cell...

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Bibliografiske detaljer
Udgivet i:Neurobiol Aging
Main Authors: Deering Brose, Rebecca, Lehrmann, Elin, Zhang, Yongqing, Reeves, Roger H., Smith, Kirby D., Mattson, Mark P.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215724/
https://ncbi.nlm.nih.gov/pubmed/30245242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.08.021
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