DNA methylation levels are associated with CRF(1) receptor antagonist treatment outcome in women with post-traumatic stress disorder

BACKGROUND: We have previously evaluated the efficacy of the CRF(1) receptor antagonist GSK561679 in female PTSD patients. While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperacti...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Pape, Julius C., Carrillo-Roa, Tania, Rothbaum, Barbara O., Nemeroff, Charles B., Czamara, Darina, Zannas, Anthony S., Iosifescu, Dan, Mathew, Sanjay J., Neylan, Thomas C., Mayberg, Helen S., Dunlop, Boadie W., Binder, Elisabeth B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215613/
https://ncbi.nlm.nih.gov/pubmed/30390684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0569-x
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