Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

There is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory phospholipase A(2) (sPLA(2)) inhibitor, LY333013, demonstrates antidotal characteristics for severe snakebite envenoming i...

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Vydáno v:Toxins (Basel)
Hlavní autoři: Lewin, Matthew R., Gutiérrez, José María, Samuel, Stephen P., Herrera, María, Bryan-Quirós, Wendy, Lomonte, Bruno, Bickler, Philip E., Bulfone, Tommaso C., Williams, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
Témata:
Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215158/
https://ncbi.nlm.nih.gov/pubmed/30241297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10100380
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