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A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease
The pathogenesis of alcoholic liver disease (ALD) remains poorly understood but is likely a multi-hit pathophysiological process. Here, we propose a hypothesis of how early mitochondrial adaptations for alcohol metabolism lead to ALD pathogenesis. Acutely, ethanol feeding causes a near doubling of h...
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| Publicado no: | Alcohol Clin Exp Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6214771/ https://ncbi.nlm.nih.gov/pubmed/30132924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13877 |
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