STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses

STAT3 is an oncogenic transcription factor exerting its functions both as a canonical transcriptional activator and as a non-canonical regulator of energy metabolism and mitochondrial functions. While both activities are required for cell transformation downstream of different oncogenic stimuli, the...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Avalle, Lidia, Camporeale, Annalisa, Morciano, Giampaolo, Caroccia, Natascia, Ghetti, Elena, Orecchia, Valeria, Viavattene, Daniele, Giorgi, Carlotta, Pinton, Paolo, Poli, Valeria
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214529/
https://ncbi.nlm.nih.gov/pubmed/30042492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0171-y
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