Translational Research Opportunities Regarding Homologous Recombination in Ovarian Cancer

Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and ruca...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Romeo, Margarita, Pardo, Juan Carlos, Martínez-Cardús, Anna, Martínez-Balibrea, Eva, Quiroga, Vanesa, Martínez-Román, Sergio, Solé, Francesc, Margelí, Mireia, Mesía, Ricard
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214122/
https://ncbi.nlm.nih.gov/pubmed/30347758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103249
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