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MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner

Non-native ligands for growth factor receptors with distinct chemical properties and different biological activities have the potential to become therapeutic applications. We previously generated MET/hepatocyte growth factor (HGF) receptor agonists using bivalent macrocyclic peptides. The highest ME...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Miao, Wenyu, Sakai, Katsuya, Imamura, Ryu, Ito, Kenichiro, Suga, Hiroaki, Sakuma, Tetsushi, Yamamoto, Takashi, Matsumoto, Kunio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213957/
https://ncbi.nlm.nih.gov/pubmed/30322054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103141
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