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Whole-Exome Sequencing Implicates SCN2A in Episodic Ataxia, but Multiple Ion Channel Variants May Contribute to Phenotypic Complexity

Although the clinical use of targeted gene sequencing-based diagnostics is valuable, whole-exome sequencing has also emerged as a successful diagnostic tool in molecular genetics laboratories worldwide. Molecular genetic tests for episodic ataxia type 2 (EA2) usually target only the specific calcium...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Maksemous, Neven, Smith, Robert A., Sutherland, Heidi G., Sampaio, Hugo, Griffiths, Lyn R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213185/
https://ncbi.nlm.nih.gov/pubmed/30314295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19103113
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