Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension

Increased growth and proliferation of distal pulmonary artery vascular smooth muscle cells (PAVSMC) is an important pathological component of pulmonary arterial hypertension (PAH). Transforming Growth Factor-β (TGF-β) superfamily plays a critical role in PAH, but relative impacts of self-secreted Ac...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kudryashova, Tatiana V., Shen, Yuanjun, Pena, Andressa, Cronin, Emily, Okorie, Evelyn, Goncharov, Dmitry A., Goncharova, Elena A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212879/
https://ncbi.nlm.nih.gov/pubmed/30274147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19102957
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