Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no structural data highlights how they interact with their partners at the interface between the inner nuclear envelope and chromatin. A large number of mutations...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Samson, Camille, Petitalot, Ambre, Celli, Florian, Herrada, Isaline, Ropars, Virginie, Le Du, Marie-Hélène, Nhiri, Naïma, Jacquet, Eric, Arteni, Ana-Andrea, Buendia, Brigitte, Zinn-Justin, Sophie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212729/
https://ncbi.nlm.nih.gov/pubmed/30137533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky736
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