Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models

Human FAT1 is overexpressed on the surface of most colorectal cancers (CRCs) and in particular a 25 amino acid sequence (D8) present in one of the 34 cadherin extracellular repeats carries the epitope recognized by mAb198.3, a monoclonal antibody which partially protects mice from the challenge with...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Grandi, Alberto, Fantappiè, Laura, Irene, Carmela, Valensin, Silvia, Tomasi, Michele, Stupia, Simone, Corbellari, Riccardo, Caproni, Elena, Zanella, Ilaria, Isaac, Samine J., Ganfini, Luisa, Frattini, Luca, König, Enrico, Gagliardi, Assunta, Tavarini, Simona, Sammicheli, Chiara, Parri, Matteo, Grandi, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212586/
https://ncbi.nlm.nih.gov/pubmed/30416985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00481
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