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MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core

Protease activated receptor-1 (PAR-1) and its ligand, matrix metalloproteinase-1 (MMP-1), are altered in several neurodegenerative diseases. PAR-1/MMP-1 signaling impacts neuronal activity in various brain regions, but their role in regulating synaptic physiology in the ventral striatum, which is im...

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Udgivet i:Sci Rep
Main Authors: Al-muhtasib, Nour, Forcelli, Patrick A., Conant, Katherine E., Vicini, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212422/
https://ncbi.nlm.nih.gov/pubmed/30385861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34551-z
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