Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib

Species generalization in the profound, modality-specific effects of Hedgehog pathway inhibition (HPI) in taste organ homeostasis and sensation is shown. With the HPI, cancer drug sonidegib, we demonstrate that the rat taste system, in addition to mouse, is regulated by Hedgehog signaling. After son...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kumari, A., Yokota, Y., Li, L., Bradley, R. M., Mistretta, C. M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212413/
https://ncbi.nlm.nih.gov/pubmed/30385780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34399-3
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