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Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction

Modular Response Analysis (MRA) is a method to reconstruct signalling networks from steady-state perturbation data which has frequently been used in different settings. Since these data are usually noisy due to multi-step measurement procedures and biological variability, it is important to investig...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Thomaseth, Caterina, Fey, Dirk, Santra, Tapesh, Rukhlenko, Oleksii S., Radde, Nicole E., Kholodenko, Boris N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212399/
https://ncbi.nlm.nih.gov/pubmed/30385767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34353-3
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