The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1 and BRD-1, also function in DNA damage repair...

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Udgivet i:PLoS Genet
Main Authors: Li, Qianyan, Saito, Takamune T., Martinez-Garcia, Marina, Deshong, Alison J., Nadarajan, Saravanapriah, Lawrence, Katherine S., Checchi, Paula M., Colaiacovo, Monica P., Engebrecht, JoAnne
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211623/
https://ncbi.nlm.nih.gov/pubmed/30383767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007701
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