Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus disease

The MHC class II region in humans is highly polymorphic. Each MHC molecule is formed by an α and a β chain, produced by different genes, creating an antigen-binding groove. In the groove there are several pockets into which antigens anchor and fit. The affinity of this fitting determines the recogni...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sarri, Constantina A., Papadopoulos, Georgios E., Papa, Anna, Tsakris, Athanasios, Pervanidou, Danai, Baka, Agoritsa, Politis, Constantina, Billinis, Charalambos, Hadjichristodoulou, Christos, Mamuris, Zissis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209194/
https://ncbi.nlm.nih.gov/pubmed/30379846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205557
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