Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled, mesoporous silica nanoparticles (MSNs), we apply an integrated SPECT/CT imaging and mathematical modeling approa...

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發表在:Nat Commun
Main Authors: Dogra, Prashant, Adolphi, Natalie L., Wang, Zhihui, Lin, Yu-Shen, Butler, Kimberly S., Durfee, Paul N., Croissant, Jonas G., Noureddine, Achraf, Coker, Eric N., Bearer, Elaine L., Cristini, Vittorio, Brinker, C. Jeffrey
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208419/
https://ncbi.nlm.nih.gov/pubmed/30382084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06730-z
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