Identification and characterization of a large family of superbinding bacterial SH2 domains

Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). Apart from a few isolated cases in viruses, no functional SH2 domain has been identified to date in prokaryotes. Here we identify 93 SH2 domains from Legionella that a...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kaneko, Tomonori, Stogios, Peter J., Ruan, Xiang, Voss, Courtney, Evdokimova, Elena, Skarina, Tatiana, Chung, Amy, Liu, Xiaoling, Li, Lei, Savchenko, Alexei, Ensminger, Alexander W., Li, Shawn S.-C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208348/
https://ncbi.nlm.nih.gov/pubmed/30382091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06943-2
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