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Biemamides A–E, Inhibitors of the TGF-β Pathway that Block the Epithelial to Mesenchymal Transition
Screening of a marine natural products library for inhibitors of TGF-β revealed five pyrimidinedione derivatives, biemamides A–E (1–5). The structures were determined by 2D NMR and HRMS experiments; absolute configurations were established by advanced Marfey’s analysis and ECD calculations. Biemamid...
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| Udgivet i: | Org Lett |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207949/ https://ncbi.nlm.nih.gov/pubmed/30160121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b01871 |
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