Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

The rs780094 single nucleotide polymorphism (SNP; C/T) of glucokinase regulatory protein gene (GCKR) is a regulatory genetic variant that has been associated with lactate levels in the fasting state. However, the association of this locus with lactate during hyperglycemia, and the mechanisms underly...

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Udgivet i:Sci Rep
Main Authors: López Rodríguez, Maykel, Fernandes Silva, Lilian, Vangipurapu, Jagadish, Modi, Shalem, Kuusisto, Johanna, Kaikkonen, Minna U., Laakso, Markku
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207693/
https://ncbi.nlm.nih.gov/pubmed/30375486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34501-9
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