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Renal medullary interstitial COX-2 is essential in preventing salt-sensitve hypertension and maintaining renal inner medulla/papilla structural integrity
Cyclooxygenase (COX)-derived prostaglandins regulate renal hemodynamics and salt and water homeostasis. Inhibition of COX activity causes blood pressure elevation. In addition, chronic analgesic abuse can induce renal injury, including papillary necrosis. COX-2 is highly expressed in the kidney papi...
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| Udgivet i: | Hypertension |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207229/ https://ncbi.nlm.nih.gov/pubmed/30354807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11694 |
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