Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc. Levels of both TLR4, as well as certain endogeno...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bhattacharyya, Swati, Wang, Wenxia, Tamaki, Zenshiro, Shi, Bo, Yeldandi, Anjana, Tsukimi, Yasuhiro, Yamasaki, Masashi, Varga, John
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207051/
https://ncbi.nlm.nih.gov/pubmed/30405628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02434
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