Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes

Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other protein. However, off-target expression seemingly unrelated to the regulatory elements in...

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Dades bibliogràfiques
Publicat a:Front Mol Neurosci
Autors principals: Laboulaye, Mallory A., Duan, Xin, Qiao, Mu, Whitney, Irene E., Sanes, Joshua R.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206269/
https://ncbi.nlm.nih.gov/pubmed/30405348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00385
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