Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis

Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63 osteosarcoma cell growth (p ≤ 0.001). IGF-I was shown to increase biglycan ex...

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Publicat a:Front Oncol
Autors principals: Aggelidakis, John, Berdiaki, Aikaterini, Nikitovic, Dragana, Papoutsidakis, Antonis, Papachristou, Dionysios J., Tsatsakis, Aristidis M., Tzanakakis, George N.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206209/
https://ncbi.nlm.nih.gov/pubmed/30406034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00470
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