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Imprinting of Repeated Influenza A/H3 Exposures on Antibody Quantity and Antibody Quality: Implications for Seasonal Vaccine Strain Selection and Vaccine Performance

BACKGROUND: Reduced seasonal influenza vaccine effectiveness (VE) was observed in individuals who received repeated annual vaccinations. Preexisting influenza antibody levels were also found inversely correlated with postvaccination titers. These reports suggest that preexisting immunity may affect...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Kosikova, Martina, Li, Lei, Radvak, Peter, Ye, Zhiping, Wan, Xiu-Feng, Xie, Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206119/
https://ncbi.nlm.nih.gov/pubmed/29672713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy327
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