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Reassessing the Role of Surrogate Endpoints in Drug Development for Heart Failure

With few notable exceptions, drug development for heart failure (HF) has become progressively more challenging and there remain no definitively proven therapies for patients with acute HF or HF with preserved ejection fraction. Inspection of temporal trends suggests an increasing rate of disagreemen...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Greene, Stephen J., Mentz, Robert J., Fiuzat, Mona, Butler, Javed, Solomon, Scott D., Ambrosy, Andrew P., Mehta, Cyrus, Teerlink, John R., Zannad, Faiez, O’Connor, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205720/
https://ncbi.nlm.nih.gov/pubmed/30354535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.034668
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